The carboxylic acid group of quinolones was modified; so, we designed new quinolones derivatives with different antioxidants using Ligand Designer from Glide (Schrodinger LLC).The cap group and the linker were optimized through trying various aliphatic and aromatic Shirts residues.A new synthesized derivatives (IIa-Vb) were synthesized by esterific

Abstract Background Variola virus (VARV) the causative agent of smallpox, eradicated in 1980, have wide spectrum of immunomodulatory proteins to evade host immunity.Recently additional biological activity was discovered for VARV CrmB protein, known to bind and inhibit tumour necrosis factor (TNF) through its N-terminal domain homologous to cellular

Necrotizing soft tissue infections are characterized by extensive and progressive deterioration of surrounding tissues.This work continues the ozone therapy topic as a complementary and therapeutic technique in patients with this type of infections, as well Tall Pier as its approach in Primary Health Care.The case of a 73-year-old patient with a di

BSTRACT Irregularities in spatial use that are not in accordance with WOMENS SOFTGOODS regional planning resulting in reduced protected and buffer zone space in PariamanCity.The research objective was to analyze the causes of the deviation in spatial use from the point of view of the sustainability of the coastal area in PariamanCity.The research m

High-temperature nanoindentation was used to reveal nano-layer size effects on the hardness of two-dimensional metallic nanocomposites.We report the existence of Shirts a critical layer thickness at which strength achieves optimal thermal stability.Transmission electron microscopy and theoretical bicrystal calculations show that this optimum arises